In new research, doctors compared two types of Prolotherapy, Dextrose Prolotherapy and Ozone Prolotherapy.1
Prolozone (TM) is a Prolotherapy technique that utilizes ozone gas, along with other therapeutic substances to stimulate healing and reduce pain in injured soft tissues and joints. Therapeutic injections of ozone into soft tissue structures, such as muscles, tendons and ligaments as well as arthritic joints for the relief of pain has been utilized for decades in medical clinics around the world. 2,3
This is what the new research found:
In the current randomized clinical trial, 80 patients with mild to moderate knee osteoarthritis were randomly assigned equally into two groups (ozone group and dextrose group). In each group, injections were repeated three times with 10-day intervals. Before the treatment and 3 months after the injections, the pain intensity was measured by using standardized testing scales.
The current study shows that prolotherapy with hypertonic dextrose or prolozone (intraarticular ozone injection) can be effectively used in the nonoperative management of patients with knee osteoarthritis.
The findings confirmed the outcome of previous studies indicating the pain killing and therapeutic effects of prolotherapy with ozone or dextrose. The pain intensity was significantly reduced after the treatment.
There was no statistically significant difference between the two groups. – Dextrose and Ozone worked the same.
In conclusion, Intraarticular injection of hypertonic dextrose or ozone could significantly decrease pain in patients with mild to moderate knee osteoarthritis, and improve their functional status.
1. Hashemi M, Jalili P, Mennati S, et al. The Effects of Prolotherapy With Hypertonic Dextrose Versus Prolozone (Intraarticular Ozone) in Patients With Knee Osteoarthritis. Anesth Pain Med. 2015 Oct 17;5(5):e27585. eCollection 2015.
2. Sanseverino E. Knee joint disorders treated by oxygen-ozone therapy. Europa Medicophysica. 1989;3:163-170.
3. Wong R. Ozonoterapia analgesica. Revista CENIC Ciencias Biologicas. 1989;20:143-150