Platelet Rich Plasma for knee osteoarthritis

Two studies from China say PRP injections will likely be more effective in the treatment of knee osteoarthritis, in terms of pain relief and self-reported function improvement at 3, 6 and 12 months follow-up, compared with other injections, including saline placebo, Hyaluronic Acid, ozone, and corticosteroids.1 Further that current evidence indicates that, compared with Hyaluronic Acid and saline, intra-articular PRP injection may have more benefit in pain relief and functional improvement in patients with symptomatic knee osteoarthritis at 1 year postinjection.2

Doctors in Turkey say “In the treatment of mild-moderate knee knee osteoarthritis, PRP was more successful than Hyaluronic Acid and ozone injections, as the application alone was sufficient to provide at least 12 months of pain-free daily living activities.”3

Doctors in Pakistan looked at soldiers who had internal derangements of knee, (torn, ruptured or deranged meniscus of the knee, or a partial or complete cruciate rupture, with or without injury to the capsular ligament of the knee, resulting in ongoing or intermittent signs and symptoms such as pain, instability, or abnormal mobility of that
knee.

In their paper, the doctors said: “Platelet Rich Plasma (PRP) is an emerging biotechnology which uses patient’s own blood components to create healing effect to their own injured tissues. . . Intraarticular PRP injection is safe and effective method in the conservative treatment of internal knee derangements.”

1 Dai WL, Zhou AG, Zhang H, Zhang J. Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. Arthroscopy. 2016 Dec 22. pii: S0749-8063(16)30780-0. [Pubmed]

2 Shen L, Yuan T, Chen S, Xie X, Zhang C. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res. 2017 Jan 23;12(1):16. [Pubmed]

3 Duymus TM, Mutlu S, Dernek B, Komur B, Aydogmus S, Kesiktas FN. Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options. Knee Surg Sports Traumatol Arthrosc. 2016 Apr 7. [Pubmed]

4 Razaq S, Ejaz A, Rao SE, Yasmeen R, Arshad MA. The Role of Intraarticular Platelet Rich Plasma (PRP) Injection in Patients with Internal Knee Derangements. J Coll Physicians Surg Pak. 2015 Sep;25(9):699-701. [Pubmed]