Prolotherapy Research - Unresolved Knee Pain |
Conclusion
The Hackett-Hemwall technique of dextrose Prolotherapy used on patients who had a duration of five years of unresolved knee pain was shown in this observational study to improve their quality of life. They reported less pain, stiffness, disability, depressed and anxious thoughts, medication and other pain therapy usage, as well as improved walking ability, range of motion, ability to work and activities of daily living. Therefore, Prolotherapy appears to be a viable treatment option for people suffering with unresolved knee pain.
About the Researchers
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Ross A. Hauser, MD., is the Medical Director of Caring Medical and Rehabilitation Services in Oak Park, IL and is a renowned prolotherapist and Natural Medicine Specialist with a national referral base seeing patients from all over the USA, and abroad. Dr. Hauser and his wife, Marion, authored the national best seller “Prolo Your Pain Away! Curing Chronic Pain with Prolotherapy,”, now in its third edition, along with a four-book topical mini series of prolotherapy books. He also spearheaded the writing of a 900-page epic sports book that discusses the use of prolotherapy for sports injuries, “Prolo Your Sports Injuries Away! Curing Sports Injuries and Enhancing Athletic Performance with Prolotherapy.” |
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Marion A. Hauser, MS, RD, is the CEO of Caring Medical and Rehabilitation Services, a comprehensive Natural Medicine Clinic in Oak Park, IL and owner of Beulah Land Nutritionals. As a registered dietitian, Marion is also a well-known speaker and writer on a variety of topics related to natural medicine and nutrition providing information for weekly e-newsletters and TV shows on a variety of health topics. Marion has recently released “The Hauser Diet: A Fresh Look at Healthy Living.”Along with her husband, Dr. Ross Hauser, Marion co-authored the national best seller entitled “Prolo Your Pain Away!, Curing Chronic Pain with Prolotherapy” along with a four-book topical mini series of prolotherapy books, as well as a comprehensive sports book discussing the use of prolotherapy for sports injuries. |
References
- Levy D. Knee injury, soft tissue. [Medscape Website]. May 8, 2006. Available at: http://www.emedicine.com/emerg/ TOPIC288.HTM. Accessed November 8, 2007.
- Medscape Medical News. Sufferers of osteoarthritis of the knee now may be pain – free 12 months after treatment. January 28, 2000. Available at: http://www.medscape.com/viewarticle/ 411438. Accessed November 11, 2007.
- Common orthopaedic procedures [American Academy of Orthopaedic Surgeons Website]. Available at: http://www.aaos. org/Research/stats/Knee%20Facts.pdf. Accessed November 28, 2007.
- Mann D. Joint replacement surgery on the rise [Medscape/ Web MD Health Website]. 2006. Available at: http://www. medscape.com/viewarticle/528464. Accessed November 8, 2007.
- Common orthopaedic procedures [American Academy of Orthopaedic Surgeons Website]. Available at: http://www.aaos. org/Research/stats/Knee%20Facts.pdf. Accessed November 28, 2007.
- Mann D. Joint replacement surgery on the rise [Medscape/ Web MD Health Website]. 2006. Available at: http://www. medscape.com/viewarticle/528464. Accessed November 8, 2007.
- Lennard T. Pain Procedures In Clinical Practice. Second Edition. Philadelphia, PA: Hanley & Belfus, Inc., 2000.
- Lennard T. Physiatric Procedures In Clinical Practice. Philadelphia,
PA: Hanley & Belfus, Inc., 1995. - Hauser R, et al. Prolo Your Pain Away! Second Edition.
Oak Park, IL, Beulah Land Press, 2004. - Dorman T. Prolotherapy In The Lumbar Spine And Pelvis.
Philadelphia, PA: Hanley & Belfus, Inc., 1995. - Hackett G, et al. Ligament And Tendon Relaxation Treated By
Prolotherapy. Fifth Edition. Oak Park, IL Gustav A. Hemwall,
1992. - Reeves KD. Prolotherapy: Present and future applications in
soft tissue pain and disability. Phys Med Rehabil Clin North Am
1995;6:917-926. - Ongley M. Ligament instability of knees: a new approach to
treatment. Manual Medicine. 1988;3:152-154. - Hackett G. Prolotherapy in whiplash and low back pain. Postgrad
Med 1960;27:214-219. - Kayfetz D. Occipital-cervical (whiplash) injuries treated by
Prolotherapy. Medical Trial Technique Quarterly. 1963; June 9-29. - Klein R. A randomized double-blind trial of dextrose-glycerinphenol
injections for chronic, low back pain. Journal of Spinal
Disorders. 1993;6:23-33. - Reeves K, et al. Randomized, prospective, placebo-controlled
double-blind study of dextrose Prolotherapy for osteoarthritic
thumb and finger joints: evidence of clinical efficacy. Journal of
Alternative and Complementary Medicine. 2000;6:311-320. - Yelland M. Prolotherapy injections, Saline injections, and
exercises for chronic low back pain: A randomized trial. Spine.
2004;29(1):9-16. - Brolinson G. Prolotherapy: Cutting edge therapy for chronic
injuries? ACC Sports Sciences Main Page. 2005, June: 1-3. - Sheeler R. Alternative treatments: Dealing with chronic pain.
Mayo Clinic Health Newsletter. April 2005. - Hackett G. Ligament And Tendon Relaxation Treated By Prolotherapy.
Springfield, IL: Charles C. Thomas, 1958. - Hackett G. Joint stabilization: An experimental, histologic study
with comments on the clinical application in ligament
proliferation. American Journal of Surgery. 1955;89:968-973. - Schwartz R. Prolotherapy: A literature review and
retrospective study. Journal of Neurology, Orthopedic Medicine and
Surgery. 1991;12:220-223. - Schmidt H. Effect of growth factors on proliferation of
fibroblasts from the medical collateral and anterior cruciate
ligaments. Journal of Orthopedic Research. 1995;13:184-190. - Liu Y. An in situ study of the influence of a sclerosing solution in
rabbit medical collateral ligaments and its junction strength.
Connective Tissue Research. 1983;2:95-102. - Maynard J. Morphological and biomechanical effects of sodium
morrhuate on tendons. Journal of Orthopedic Research. 1985;
3:236-248. - Hackett G. Prolotherapy for headache. Headache. 1962;3-11.
- Hackett G. Low back pain. The British Journal of Physical Medicine.
1956;19:25-35. - Reeves K, et al. Randomized, prospective double-blind placebocontrolled
study of dextrose Prolotherapy for knee osteoarthritis
with or without ACL laxity. Alternative Therapies. 2000;6:311-320. - Ongley M, et al. Ligament instability of knees: A new approach
to treatment. Maunual Medicine. 1988;3:152-154. - Reeves K, et al. Randomized, prospective double-blind placebocontrolled
study of dextrose Prolotherapy for knee osteoarthritis
with or without ACL laxity. Alternative Therapies. 2000;6:311-320. - Hackett G. Ligament And Tendon Relaxation Treated By Prolotherapy.
Third Edition. Springfield, IL: Charles C. Thomas, Publisher.
1958. - Hackett G. Referred pain and sciatica in diagnosis of low back
disability. Journal of American Medical Association. 1957;163:
183-185. - Hackett G. Joint stabilization. American Journal of Surgery. 1955;
89:968-973. - Tepper S, et al. Factors associated with hip osteoarthritis: Data
from the first national health and nutrition examination
survey (NHANES-1). American Journal of Epidemiology. 1993;
137:1081-1088. - Schouten J, et al. A 12 year follow up study in the general
population on prognostic factors of cartilage loss in osteoarthritis
of the knee. Annals of the Rheumatic Diseases. 1992;51:932-937. - Cooper C, et al. Occupational activity and osteoarthritis of the
knee. Annals of the Rheumatic Diseases. 1994;53:90-93. - Hauser R, et al. Prolo Your Pain Away! Second Edition. Oak Park,
IL: Beulah Land Press, 2004. - Adams M. An analysis of clinical studies of the use of
crosslinked hyaluronan, hylan, in the treatment of
osteoarthritis. The Journal of Rheumatology. 1993;20:16-18. - Stovitz S. NSAIDs and musculoskeletal treatment. The Physician
and Sports Medicine. 2003;31:35-52. - Prolotherapy: government review identifies gaps in the scientific
evidence. The Back Letter. 2000;15(4):42. - Liu Y. An in situ study of the influence of a sclerosing solution in
rabbit medial collateral ligaments and its junction strength.
Connective Tissue Research. 1983;2:95-102. - Hauser R. Prolotherapy: An Alternative To Knee Surgery. Oak Park,
IL: Beulah Land Press. 2004;pp.56-58. - Maynard J. Morphological and biochemical effects of sodium
morrhuate on tendons. Journal of Orthopedic Research. 1985;3:
236-248. - Schmidt C. Effect of growth factors on the proliferation of
fribroblasts from the medial collateral and anterior cruciate
ligaments. Journal of Orthopedic Research. 1995;13:184-190. - Hauser R. Prolo Your Sports Injuries Away! Oak Park, IL: Beulah
Land Press, 2001;pp.264-287. - Ongley M. Ligament instability of the knees: a new approach to
treatment. Manual Medicine. 1988;3:152-154. - Reeves K. Randomized prospective double-blind placebocontrolled
study of dextrose Prolotherapy for knee osteoarthritis
with and without ACL laxity. Alternative Therapies 2000;2:68-70. - IBID.
Acknowledgements
Data Collection:
Doug Puller
BS Chemical Engineering
Spirit Lake, ID
Statistical Analysis:
Anne M. Drougas, PhD
Associate Professor of Finance & Economics
Dominican University – Brennan School of Business
7900 West Division Street, River Forest, IL 60305
(708) 524-6938
Carol Tallarico, PhD
Associate Professor of Finance & Economics
Dominican University – Brennan School of Business
7900 West Division Street, River Forest, IL 60305
(708) 351-8961
Dave Gruen
Senior Vice President, Consulting Division BolderImage
707 N. Iowa Ave.
Villa Park, IL 60181
(630) 279-4000
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