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About Prolotherapy offers the following resources for those wanting to explore prolotherapy further...

Capsular Ligament Laxity

Prolotherapy Research Chronic Neck Pain: This article is a free access article on the use of Prolotherapy for Chronic Neck Pain – Print the entire article using ADOBE PDF Chronic Neck Pain

Chronic Neck Pain: Making the Connection Between Capsular Ligament Laxity and Cervical Instability

Danielle Steilen* Ross Hauser, Barbara Woldin and Sarah Sawyer

Caring Medical Regenerative Medicine Clinics


In this article from Caring Medical, researchers say:
“based on clinical studies and experience with patients who have visited our chronic pain clinic with complaints of chronic neck pain, we contend that prolotherapy offers a potentially curative treatment option for chronic neck pain related to capsular ligament laxity and underlying cervical instability.” We conducted a review of the literature published up to December 2013 on the diagnostic and treatment modalities of disorders related to chronic neck pain and concluded that, despite providing temporary relief of symptoms, these treatments do not address the specific problems of healing and are not likely to offer long-term cures. Free access to the full article Chronic Neck Pain: Making the Connection Between Capsular Ligament Laxity and Cervical Instability

As far back as 1962, research has appeared supporting the use of Prolotherapy for problems of the neck and head. 1 In fact at one point, researchers claimed that Prolotherapy could only benefit neck problems. 2 This was do to the great variation of technique making a controlled study nearly impossible.3 The same researchers also noted that despite the variation of technique “Side effects related to prolotherapy for back and neck pain, such as temporary post-injection pain, stiffness, and bruising, are common and benign. Adverse events related to prolotherapy for back and neck pain are similar in nature to other widely used spinal injection procedures.”4

In 2007, researchers found that in cases of whiplash, Prolotherapy proved to be a very effective treatment in a study of 15 patients with whiplash and other cervical neck problems.5 In other research appearing in 2007, Caring Medical researchers found that while  current conventional therapy for unresolved neck pain such as pain killers, non-steroidal anti-inflammatory drugs, anti-depressant medications, epidural or other steroid shots, trigger point injections, surgical treatments that range from disc replacements to fusions, the results of such therapies often leave the patients with residual pain. Because of this, many patients with chronic neck pain are searching for alternative treatments for their pain. One of the treatments they find promising is prolotherapy. You can read and download as free access article: Prolotherapy for chronic neck pain.

1. Hackett, et al. Prolotherapy for headache. Pain in the head and neck, and neuritis. Headache. 1962 Apr;2:20-8.
Only case reports were found supporting the pursuit of controlled clinical studies of prolotherapy for chronic neck pain.

2. Kim SR, Stitik TP, Foye PM, Greenwald BD, Campagnolo DI. Critical review of prolotherapy for osteoarthritis, low back pain, and other musculoskeletal conditions: a physiatric perspective. Am J Phys Med Rehabil. 2004 May;83(5):379-89.

3. Dagenais S, Haldeman S, Wooley JR. Intraligamentous injection of sclerosing solutions (prolotherapy) for spinal pain: a critical review of the literature. Spine J. 2005 May-Jun;5(3):310-28.

4. Dagenais S, et al. Side effects and adverse events related to intraligamentous injection of sclerosing solutions (prolotherapy) for back and neck pain: A survey of practitioners. Arch Phys Med Rehabil. 2006 Jul;87(7):909-13.

5. Hooper RA, Frizzell JB, Faris P. Case series on chronic whiplash related neck pain treated with intraarticular zygapophysial joint regeneration injection therapy.Pain Physician. 2007 Mar;10(2):313-8.