Systemic inflammation in older adults with osteoarthritis


Medical university researchers in Spain examined the role of systemic inflammation in older adults with osteoarthritis and the factors associated with osteoarthritic progression, pain and functional impairment.

  • Excessive mechanical loading of the joint may lead to stress-induced inability of healing factors to multiply and fix the problems of the joint.
  • Where natural anti-inflammatory factors are not being produced, there is an increased production of pro-inflammatory mediators (chronic inflammation).
  • Premature deterioration would result in a lower ability of chondrocytes (cartilage building cells)  to counteract the cartilage deterioration and prevent the progression of osteoarthritis

The researchers then explained that a wide range of evidence indicates that intra-articular injection of adipose-derived mesenchymal stem cells, alone or associated to growth factors and/or scaffolds, can improve cartilage quality in osteoarthritis. However, cell signaling or the paracrine effect may have therapeutic potential in the down-regulation of inflammatory and catabolic mediators and exert protective effects by countering inflammatory stress.1

  • In Caring Medical research published in 2013 in the medical journal Clinical medicine insights. Arthritis and musculoskeletal disorders, we were able to show that Prolotherapy, Platelet rich Plasma Therapy, and in this instance bone marrow aspirate (stem cells and healing factors)  supported chondrogenesis (Cartilage growth and repair) by enhancing the availability of pro-chondrogenic microenvironmental factors. In essence an environmental change from diseased to healing within the osteoarthritic joint.

This was achieved in our study by a combination of the above treatments.

While treatments based on either stem cells or the other mentioned treatments show effectiveness for osteoarthritis as a stand alone or single therapy, treatments that combine these modalities may be especially promising. 

Related articles:

Ross Hauser, MD

1 Platas J, Guillén MI, del Caz MDP, et al. Paracrine effects of human adipose-derived mesenchymal stem cells in inflammatory stress-induced senescence features of osteoarthritic chondrocytes. Aging (Albany NY). 2016;8(8):1703-1717. [Pubmed]