Stem Cells and PRP and Exercise for Knee Osteoarthritis

Doctors in Australia have just publish their case studies on Stem Cells and PRP and Exercise for Knee Osteoarthritis.

Writing in the Journal of Pain Research, the doctors acknowledge that Knee osteoarthritis is associated with persistent joint pain, stiffness, joint deformities, ligament damage, and surrounding muscle atrophy. The complexity of the disease makes treatment difficult. There are no therapeutic drugs available to halt the disease progression, leaving patients dependent on pain medication, anti-inflammatory drugs, or invasive knee replacement surgery.

Four patients with a history of unresolved symptomatic knee osteoarthritis were investigated for the therapeutic outcome of combining an exercise rehabilitation program with intra-articular injections of autologous stem cells (in this case StroMed – stromal vascular fraction cells concentrated by ultrasonic cavitation from lipoaspirate – and platelet-rich plasma (PRP).

The Knee Injury and Osteoarthritis Outcome Score questionnaire (KOOS) was administered along with physical function tests over a 12-month period.

  • The first patient achieved a maximum therapeutic outcome of 100 in all five KOOS subscales (left knee), and 100 for four subscales (right knee).
  • The second patient scored 100 in all five KOOS subscales (left knee), and greater than 84 in all subscales (right knee).
  • Treatment of the third patient resulted in improved outcomes in both knees of >93 for four KOOS subscales, and 60 for the Function in Sport and Recreation subscale.
  • The fourth patient improved to 100 in all five KOOS subscales. In all patients, the physical function “Get-up and Go” test and “Stair Climbing Test” returned to normal (a value of zero).

This case series indicates that improved outcomes may be obtained when autologous stromal vascular fraction (StroMed) cell therapy is combined with traditional exercise practices and PRP for osteoarthritis. 1

1. Gibbs N, Diamond R, Sekyere EO, Thomas WD. Management of knee osteoarthritis by combined stromal vascular fraction cell therapy, platelet-rich plasma, and musculoskeletal exercises: a case series. J Pain Res. 2015 Nov 9;8:799-806.

2. Ross Hauser, MD Combined Stem Cell Therapy and Platelet Rich Plasma Therapy treatments